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The Science Behind hADSC-CM and hADSC-Exosomes: Transforming Skin Regeneration

The Science Behind hADSC-CM and hADSC-Exosomes: Transforming Skin Regeneration

At MESCH, we believe the future of skincare lies in the power of cellular regeneration. Stem cell science is revolutionizing how we care for our skin, with Human Adipose-Derived Stem Cell Conditioned Media (hADSC-CM) and Exosomes (hADSC-Exosomes) leading the charge. These extraordinary ingredients, backed by cutting-edge research, offer unparalleled potential to repair, renew, and transform the skin from within.


EXOGLO, MESCH’s flagship serum, harnesses these advanced biotechnologies to address skin health at its foundation, delivering a vision of radiant, resilient skin that evolves with you. Here’s why these innovations are more than just ingredients—they are the next step in skincare’s evolution.


hADSC-CM: The Blueprint for Renewal

Stem cells are nature’s architects, orchestrating the repair and regeneration of tissues. hADSC-CM captures the very essence of this power, delivering a nutrient-rich elixir of growth factors, peptides, and cytokines. These bioactive molecules act as cellular messengers, guiding the skin to rejuvenate and heal itself.


How It Works

hADSC-CM is a symphony of signals that:

  • Stimulate Cellular Renewal: Encouraging skin cells to regenerate, improving texture and tone.
  • Promote Collagen and Elastin Synthesis: Reinforcing skin’s structure, leading to improved firmness and elasticity.
  • Soothe and Repair: Reducing inflammation while accelerating the skin’s natural healing processes.

Scientific Validation

A study published in Biomedical Dermatology demonstrated the profound impact of hADSC-CM in skincare. Participants experienced firmer skin, enhanced hydration, and improved elasticity within eight weeks. This research underscores its transformative potential, redefining what skincare can achieve.

(Source: Kyung Hye Kim, Yun-Sik Kim, et al., 2019)


hADSC-Exosomes: Nature’s Perfect Messengers

Exosomes are the unsung heroes of cellular communication. These nanosized vesicles, derived from hADSCs, carry proteins, lipids, and RNA to neighboring cells, instructing them to repair, regenerate, and thrive. In skincare, hADSC-Exosomes unlock the potential for targeted rejuvenation at the cellular level.


How They Work

  • Deliver Precision Repair: Sending targeted instructions to optimize skin function.
  • Stimulate Collagen and Elastin: Restoring the skin’s resilience and youthful bounce.
  • Calm and Balance: Reducing redness and inflammation, soothing even the most sensitive skin.

Scientific Validation

Research published in Cosmetics revealed that hADSC-Exosomes effectively brightened skin tone and reduced pigmentation. Their ability to promote dermal regeneration was linked to enhanced elasticity and a reduction in visible signs of aging, delivering radiant, revitalized skin.

(Source: W. Kim, S. Lee, et al., 2020)


The Synergy of hADSC-CM and hADSC-Exosomes

The true magic happens when these two technologies are combined, amplifying each other’s benefits for truly transformational results:

Total Skin Renewal

hADSC-CM creates the ideal environment for repair, while hADSC-Exosomes deliver precise cellular instructions to optimize regeneration.

Comprehensive Anti-Aging

Together, they target multiple signs of aging, including fine lines, wrinkles, sagging, and uneven tone.

Barrier Restoration

Strengthens the skin’s natural defenses, improving hydration and resilience to environmental stress.

Accelerated Recovery

Enhances the skin’s ability to heal and adapt, promoting a smoother, more youthful appearance.


Research at the Core

At MESCH, we don’t just believe in results—we validate them. Studies confirm the efficacy of hADSC-CM and hADSC-Exosomes:

  • Enhanced Elasticity and Hydration: hADSC-CM improves dermal density, elasticity, and moisture retention within eight weeks (Biomedical Dermatology, 2019).
  • Pigmentation Reduction: hADSC-Exosomes brighten skin and reduce pigmentation, leading to a more even tone (Cosmetics, 2020).
  • Accelerated Skin Healing: hADSC-Exosomes promote cell proliferation and tissue repair, aiding in regeneration (Stem Cell Research & Therapy, 2022).

(Sources: Kyung Hye Kim et al., 2019; W. Kim et al., 2020; Yang Zhou et al., 2022)


The Future of Skin Regeneration with EXOGLO

At MESCH, we envision a world where skincare doesn’t just address concerns—it evolves with you. EXOGLO is the embodiment of this vision, pairing hADSC-CM and hADSC-Exosomes with other advanced actives like VC-IP (Vitamin C Derivative) and a lipid complex comprised of Phospholipids and Ceramides.

This unique combination delivers unparalleled benefits:

  • Brighten: Revives dull, uneven skin for a luminous glow.
  • Renew: Smooths and refines texture with enhanced cellular turnover.
  • Regenerate: Restores structure and firmness, reducing visible signs of aging.
  • Hydrate: Strengthens the skin barrier, ensuring long-lasting moisture.

Embrace Your EXOGLO

hADSC-CM and hADSC-Exosome technology is more than science—it’s a new paradigm. 

A paradigm promising radiant, resilient skin that embraces the future while honoring its foundation. With EXOGLO, MESCH leads the way, bringing together the most advanced regenerative ingredients to redefine what skincare can be.