We are entering a new biological epoch in skincare—one that moves beyond moisturisers and serums into the domain of cellular communication and regenerative medicine. At the centre of this shift lies a microscopic powerhouse few have heard of, yet many will soon rely on: Exosomes.
Marie Claire first reported on the significance of exosomes ushering in a new era for skincare and Aesthetics back in 2023. Recently, Vogue referred to it the "regenerative medicine trend that everyone is talking about" and Elle called it the game changer that is "bigger than botox". But, we have been in this space since long before any magazine reporter caught on. So, let us explain in this article some of the science and key publications.
Exosomes are nano-scale extracellular vesicles, once dismissed as cellular byproducts, are now considered master regulators of regeneration—capable of influencing how our cells behave, repair, and even remember youth. GQ and Vogue share various testimonials on the unique efficacy and benefits of exosome therapy.
What are exosomes—and why do they matter for your skin?
Exosomes are bio-intelligent couriers, released naturally by cells to deliver messages that orchestrate healing, growth, and balance. Derived from mesenchymal stem cells, they contain a cargo of proteins, lipids, growth factors, cytokines, and genetic material (mRNA and microRNA). Once absorbed by target cells like fibroblasts or keratinocytes, they modulate biological pathways that underpin skin health and renewal.
For more detail on the practical implications of anyone considering using an exosome product, Elle shares "everything you need to know about exosomes". And now we're going to get real nerdy. Buckle up!
Scientific research has demonstrated that stem cell-derived exosomes can:
• Stimulate collagen and elastin synthesis
• Accelerate cell turnover and tissue repair
• Modulate inflammation and oxidative stress
• Improve barrier function and hydration
• Rejuvenate senescent cells and suppress the senescence-associated secretory phenotype (SASP)
Senescent cells, while metabolically active, no longer divide. Instead, they secrete pro-inflammatory factors that damage surrounding tissue and degrade skin quality. Exosomes have been shown in vitro to help suppress this inflammatory cascade, restoring balance to the skin’s microenvironment.
This is not surface-level skincare—it is biological reprogramming at the cellular level.
The Science Behind the Signal
Exosomes are not a one-size-fits-all solution—their efficacy depends on source cell type and purification method. Exosomes derived from Human Adipose-Derived Mesenchymal Stem Cells (hADSCs) have gained particular attention due to their high regenerative potential and clinical safety profile.
These hADSC exosomes are rich in VEGF, TGF-β, EGF, IGF, and other bioactive molecules that have been shown to:
• Suppress SASP markers and rebalance aging tissue
• Promote angiogenesis, improving circulation and nutrient delivery
• Activate extracellular matrix remodelling, supporting firmness and elasticity
• Influence epigenetic signalling, helping aging skin cells behave more youthfully
This isn’t merely skincare. It’s cellular optimisation through targeted bio-signalling. Forbes hails this as the New Frontier of Skincare.
EXOGLO: Translating Science into Skin Transformation
At MESCH, we believe in shaping human evolution for the better—starting with the cell. EXOGLO is our breakthrough serum that delivers next-level regenerative power through biotechnology.
Key features of the formulation include:
• hADSC-derived exosomes
• Human Stem Cell Conditioned Media, offering a broader range of growth factors
• Ascorbyl Tetraisopalmitate (VC-IP) – a lipid-soluble form of Vitamin C, clinically studied for collagen synthesis and photoprotection
• Liposome encapsulation, mimicking cellular membranes and improving ingredient stability and penetration
• A Lipid Delivery Complex (Phosphatidylcholine, Ceramides, Phytosphingosine), which both strengthens the barrier and facilitates deep transdermal delivery
This formulation doesn’t just enhance appearance—it restores function, helping skin communicate, regenerate, and evolve better.
The Result: Skin That Regenerates
Unlike traditional skincare that reacts to damage already done, EXOGLO’s bio-intelligent design supports skin longevity from the inside out. Ingredient studies support benefits including:
• Smoother texture and reduced visible fine lines
• Brighter, more even skin tone
• Improved elasticity and dermal density
• Rebalanced inflammatory responses
• Enhanced hydration and skin barrier resilience
This is the future of skin wellness—rooted in regeneration.
The future of skincare isn’t anti-aging—it’s cellular evolution.
And it begins now.
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Embrace Your EXOGLO,
Chris Mesh (Co-founder)
